The human brain undergoes constant changes as we learn new skills or recover from potentially life-altering injuries, such as limb loss or disease. This well-known ability to “rewire” neural connections that are established at birth — a phenomena known as neuroplasticity — has been extensively demonstrated in animal models which show both structural and functional changes at multiple levels of the nervous system. However, human studies are often limited to only post-injury observations of highly variable injuries and recoveries. Furthermore, human neuroimaging studies involving nerve injuries are virtually non-existent. Our study will be the first to non-invasively measure neuroplasticity in the human brain before and following surgical repair of cranial nerves using the simultaneous measurement of detailed facial motor control (kinematics) and brain activity using an MEG compatible real-time motion tracking system developed with our collaborators at the PRISM lab at Holland-Bloorview Kids Rehabilitation Hospital. Our goal is to establish which factors influence the speed or success of recovery of facial motor control and sensation in these clinical populations. The resulting technology will have broad future application in other clinical disorders affecting the cranial nerves, such as Bell’s Palsy, dysphagia, motor neuron disease, and others for which there is currently no non-invasive technology available to assess recovery at the behavioural or brain level.